8$B7n9f(B

$B!!Bh(B69$B9f(B

$BH/9TF|(B H14.8 .1

$BH/9T

$BJT=8@UG$

$B!!(B
$B#T#E#L!!#0#5#8#4!J#6#6!K#2#6#0#0(B

$B!!(B

$B(!

7$B7n(B17$BF|$NM8E206u9A$K$D$$$F$+$iJ,$+$C$F$-$^$7$?!#$^$:=P9q/$7$GE~Ce$9$k$3$H$,=PMh$^$9!#;d$OHt9T5!$K>h$k$N$b=i$a$F$@$C$?$N$G!"@J$K$D$$$F$+$i$:$C$H%I%-%I%-$7$F$$$^$7$?!#!V$3$s$J=E$$$b$N$,Ht$V$N$@$m$&$+!)!W$J$I$H$$$m$s$J;v$r9M$($F$$$^$7$?$,!"N%N&$7$?;~$O62$$$H$$$&46$8$O$7$^$;$s$G$7$?!#(B

$B!!%0%"%`$K$D$$$?$N$O!"$b$&F|$,JQ$o$C$F#1#2;~2a$.$G$7$?!#$=$3$+$i!"h$C$?$j$H!"?2>2$K$D$$$?$N$O8aA0#3;~$G$7$?!#0lF|L\$O;TFb4Q8w$K=P3]$1$^$7$?!#4Q8w$h$j$bElKL=P?H$@$H8@$&>/$7JQ$o$C$?%P%9%,%$%I$5$s$NOC$,3Z$7$+$C$?$G$9!#M-L>$JNx?ML($+$i$N7J?'$O@d7J$G$7$?!#;TFb4Q8w$,=*$o$C$?8e$O!"%[%F%k$NA0$N%S!<%A$X9T$C$F1K$.$^$7$?!"$H$O$$$C$F$b!";d$O1K$2$J$$$N$G@u$$=j$GM7$s$G$$$?$@$1$G$9$1$I!D!#(B

$B!!(B2$BF|L\$O%Q%i%;!<%j%s%0$H%P%J%J%\!<%H$r$7$^$7$?!#%Q%i%;!<%j%s%0$O!"3$$N>e$rA%$G$R$C$Q$C$F$b$i$$!"6u$rHt$V$H$$$&$b$N$G$7$?!#3$$,@($/@D$/$F$-$l$$$G$7$?$,!";W$C$?0J>e$K3$LL$+$i9b$/$F!">/$762$+$C$?$G$9!#(B

$B!!#3F|L\$O!"%7!<%&%)!<%+!<$N%D%"!<$K9T$-$^$7$?!#3$$K@x$k$H5{$,$$$C$Q$$$$$F46F0$7$^$7$?!#F,$K$+$V$k%X%k%a%C%H$,$H$F$b=E$/$F8*$,DK$/$J$j$^$7$?!#(B($BH!#(B)$BLk$OKhF|%7%g%C%T%s%0$K=P$+$1$^$7$?!#%;!<%k$N>&IJ$,Bt;3$"$C$?$N$G!";d$b0l$DGc$$$^$7$?!#:G=i$O!"%+!<%I$r;H$C$FGcJ*$9$k$3$H$K6[D%$7$F!"$J$+$J$+Gc$&M&5$$,$G$^$;$s$G$7$?!#$7$+$77k6IFs$D$b%+!<%I$GGc$C$F$7$^$$$^$7$?!#$3$l$+$i@aLs@83h$r$7$J$$$H!D$H$$$&46$8$G$9!#(B

$B!!(B$B:G=*F|$NM

$B!!:#7n9f$O!"#8!A(B10$B7n$K$+$1$FHt;6$9$k%-%/2J2VJ4$K$D$$$F$*OC$7$$$?$7$^$9!#%-%/2J$r4^$a0J2<$N@$3&$N;0Bg2VJ4>I$,$"$j$^$9!#(B

$B@$3&$N;0Bg2VJ4>I(B

$B%h!<%m%C%Q$NKRAp%+%b%,%d(B($B%$%M2J(B)$B2VJ4>I(B
$B%"%a%j%+$N%V%?%/%5(B($B%-%/2J(B)$B2VJ4>I(B
$BF|K\$N%9%.(B($B%9%.2J(B)$B2VJ4>I(B
$B!!%-%/2J2VJ4>I$NBeI=E*$J?"J*$O!"Bg$-$/!"%V%?%/%5!"%*%*%V%?%/%5$J$I$NKL%"%a%j%+$+$iF~$j9~$s$@2VJ4$H!"F|K\8EMh$+$i<+@8$7$F$$$k%h%b%.!"%(%>%h%b%.!"$^$?!"2O@nI_$r2+?'$/@w$a$kIwJ*;m$N0l$D$H$J$C$F$$$k%;%$%?%+%"%-%N%-%j%s%=%&$,$"$2$i$l$^$9!#(B
$B%*%*%V%?%/%5(B $B%V%?%/%5(B $B%h%b%.(B $B%(%>%h%b%.(B

$BHt!!;6!!4|!!4V(B

8$B7n!A#97n(B 8$B7n!A(B10$B7n(B

8$B7n!A(B10$B7n(B

$B@80i>l=j!'(B$B!!;T39CO!"6u$-CO$^$?$O!"2O@nI_$J$I?eJU$K9%$s$G72@8$9$k!#(B $B@80i>l=j!'(B$B!!;T39CO!"DiKI!"6u$-CO(B
$B2VJ4%a%b!'(B$BB?G/Ap%V%?%/%5$O!V%^%C%+!<%5!<$NCV$-EZ;:!W$H8F$P$l!"5"2=?"J*$H$7$FF|K\$KF~$C$F$-$?Ev=i!"B?$/$N?M$,G:$^$5$l$^$7$?!#(B $B2VJ4%a%b!'(B$BF|K\8E$/$+$i<+@8$7$F$$$k?"J*$G$9!#

$B2VJ4>I$NF|>o@83h>e$NCm0UE@(B

$B!|(B$B860x?"J*$,<~JU$K$"$k;~$O!"=|Ap$9$k!#(B

$B!|Iw$N6/$$F|$O!"860x?"J*$,72@8$7$F$$$k>l=j$K$G$-$k$@$16a$E$+$J$$$h$&$K$7$^$7$g$&!#(B

$B!|30=P$N;~$O!"%^%9%/$d%a%,%M$rCeMQ$7!"2VJ4$N5[F~$rKI$0$h$&$K$7$^$7$g$&!#(B

$B!|Dq93NO$,Dc2<$9$k$H!"%"%l%k%.!<>I>u$,=P$k860x$K$J$j$^$9$N$G!"IaCJ$+$i7r9/$K5$$r$D$1$^$7$g$&!#(B

$B!!(B$B<+8J7l@6E@4c$K$D$$$F(B

$B:#7n9f$O3$DED4:^Lt6I$NCf_7@h@8$K<+8J7l@6E@4c$K$D$$$F$*OC$7$7$F$$$?$@$-$^$9!#(B

$B:#F|$O<+8J7l@6E@4c1U$K$D$$$FOC$r$5$;$F$$$?$@$-$^$9!#$3$NE@4c1U$O!"<+8J$N7l1U$+$i7l@6@.J,$rJ,N%$7$F!"$=$l$rD4@=$7$?E@4c1U$G$9!#$3$NE@4c1U$O!"

$B!!N^$N5!G=$H$7$F$O!V4pACJ,Hg!W$H$$$C$F>o$KL\$NI=LL$rG($i$7$F$$$kN^$H!VH?l9g$K=P$kN^$N(B2$Bt:nMQ!":Y6]$d%&%$%k%9$J$I$N;&6]:nMQ!"3QKl$NBeeHi$N@5>o$JBeeHi:YK&@.D90x;R!J(BEGF:epidermal growth factor$B!K$d%S%?%_%s#A$,4^$^$l$F$$$k$N$G$9!#(B

$B!!=EMW$J3QKl<@45!J%I%i%$%"%$Ey!K$N>l9g!"N^1U$N4pACJ,Hg$K2C$(!"$3$l$i$NI,MW0x;R$r4^$`H?/$7$F$$$k0Y$K>I>u$,0-2=$9$k!#(B

$B!!$9$J$o$A!"4c$NI=LL$,4%$/$+$i>I>u$,0-2=$9$k$N$G$O$J$/!"I,MW$J@.J,$,3Q7kKl$K6!5k$5$l$J$$0Y$K!">I>u$,$R$I$/$J$k$H$$$&?7$7$$9M$(J}$,$"$j$^$9!#$7$+$7$J$,$i!"$^$@N^$HF1$8@.J,$r4^$s$@E@4cLt!J?M9)N^1U!K$O3+H/$5$l$F$*$i$:!":G6a$N8&5f$K$h$j7l1U$N7l@6@.J,$O!"N^$N@.J,$KHs>o$K6a$$;v$,2r$C$F$-$^$7$?!#$=$3$G!"<+$i$N7l@6@.J,$GE@4c$9$kJ}K!$,9M$(=P$5$l$?$N$G$9!#(B

$B!!0J>e!":G6a$N%H%T%C%/%9$K$D$$$FOC$r$5$;$F$$$?$@$-$^$7$?!#$=$l$G$O3'MM$*Bg;v$K$72<$5$$!#(B

$B(!$*CN$i$;(!(B

$B#87n#1#3F|(B($B2P(B)

$B#87n#1(B4$BF|(B($B?e(B)$B!#5F|(B($BLZ(B)$B#1#6F|(B($B6b(B) $B#87n#1(B7$BF|(B($BEZ(B)
$BJ?>o$I$*$j(B $B5Y!!!!!!?G(B $BJ?>o$I$*$j(B

$B!!#87n#5F|!J7n!K!A#1#3F|!J2P!K$^$G$N4V!"?z;3=w3X1`Bg3X$NJ?LnM'H~$5$s$,!"%$%s%?!<%7%C%W$K$FEv1!$K

$B%D%8%J%+%3%s%?%/(B$B%H$+$i$N$*CN$i$;(B

$B!!(B$B%D%8%J%+%3%s%?(B$B%/%H4c6@It$N%j%K%e!<%"%k%*!<%W%s$KB3$$$F!"%D%8%J%+0e1!2#$K!"%D%8%J%+%3%s%?%/%H4c6@It%G%b<<$rA}@_$7$^$7$?!#FCGd%3!<%J!NEW$B%b%G%k$r$H$jB7$($F$*$j$^$9!#($BFCCm;XDj!"B>$N%l%s%:$O4^$^$J$$(B)$B$N%;%C%H2A3J$G(B$B#6#0#0#01_(B$B$HDc2A3J$K$FHNGd$7$F$*$j$^$9!#$^$?FCGd%3!<%J!$B#2#0!s(BOFF$B!"(B$BCf$K$O(B$B!"(B$B#1!$#0#0#01_!A(B$B$*5a$a$K$J$l$k$b$N$b$"$l$^$9!#(B

$B"($4

$B%9%?%C%U0lF1!"3'MM$N$4MhE9$r$*BT$A$7$F$*$j$^$9!#(B